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-indazoles 1a–m with distinctive substituted aldehydes 2a–q/benzyl alcohols 5a–e/styrenes 6a–e in as many as 87% yields.7 ?M, whilst seventy five exhibited increased potency but a bit reduced selectivity towards human CSE. These inhibitors were synthesized employing a six-bromoindole scaffold, with various useful teams hooked up by means of

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